Repressive Histone Code Modifications Leading to Chromatin with a Malignancy: Interplay of Epigenetic Bovine Leukemia Virus-Associated B-Cell Suppression of Viral Gene Expression in
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چکیده
Published Ahead of Print 28 March 2007. 2007, 81(11):5929. DOI: 10.1128/JVI.02606-06. J. Virol. Van den Broeke Pierre Kerkhofs, Arsène Burny, Philippe Martiat and Anne Makram Merimi, Pavel Klener, Maud Szynal, Yvette Cleuter, Repressive Histone Code Modifications Leading to Chromatin with a Malignancy: Interplay of Epigenetic Bovine Leukemia Virus-Associated B-Cell Suppression of Viral Gene Expression in
منابع مشابه
Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code.
Ovine leukemia/lymphoma resulting from bovine leukemia virus infection of sheep offers a large animal model for studying mechanisms underlying leukemogenesis. Silencing of viral information including Tax, the major contributor to the oncogenic potential of the virus, is critical if not mandatory for tumor progression. In this study, we have identified epigenetic mechanisms that govern the compl...
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